The Cancer EPIgenetics and iMMunotherapY team (CEPIMMY) has been created in January 2023 through a Chair of Excellence from the Laboratory of Excellence for Innovation in Signal Transduction Pathways in Life Sciences (Labex SIGNALIFE), a program of excellence hosted by the Université Côte d’Azur. The team focuses on hematological malignancies, which are common and aggressive cancers with limited treatment options. Our research interests are categorized in three axes: 1) investigating the mechanistic events underpinning the development and progression of blood cancers caused by malfunctioning of epigenetic processes, 2) exploring new combinatorial epigenetic therapies and 3) understanding how epigenetic mechanisms modulate the dynamic cellular interactions between the tumor and the (innate) immune system.

Our research vision integrates basic and translational approaches, combining epigenetic-focused themes as well as human systems, mouse models and innovative methods to investigate the causes of blood cancer and enhance the applicability of epigenetic therapies and immunotherapies.

Publications

Focus

Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML.

Authors Salmon JM, Todorovski I, Stanley KL, Bruedigam C, Kearney CJ, Martelotto LG, Rossello F, Semple T, Arnau GM, Zethoven M, Bots M, Bjelosevic S, Cluse LA, Fraser PJ, Litalien V, Vidacs E, McArthur K, Matthews AY, Gressier E, de Weerd NA, Lichte J, Kelly MJ, Hogg SJ, Hertzog PJ, Kats LM, Vervoort SJ, De Carvalho DD, Scheu S, Bedoui S, Kile BT, Lane SW, Perkins AC, Wei AH, Dominguez PM, Johnstone RW

Cancer discovery Mar 2022

 TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.

Authors Dominguez PM, Ghamlouch H, Rosikiewicz W, Kumar P, Béguelin W, Fontán L, Rivas MA, Pawlikowska P, Armand M, Mouly E, Torres-Martin M, Doane AS, Calvo Fernandez MT, Durant M, Della-Valle V, Teater M, Cimmino L, Droin N, Tadros S, Motanagh S, Shih AH, Rubin MA, Tam W, Aifantis I, Levine RL, Elemento O, Inghirami G, Green MR, Figueroa ME, Bernard OA, Aoufouchi S, Li S, Shaknovich R, Melnick AM

Cancer discovery Oct 2018

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- Master Student: Calixte Calaud (M1)
 
My name is Calixte Calaud and I am from Burgundy. In Dijon I obtained a Bachelor’s degree in Cellular Biology and Physiology from the Université de Burgundy. Through years of study, I realized that I love genetics, and for that reason I moved to Nice to pursue a Master’s degree in Genetics and Development in the Université Côte d’Azur. From February to June 2023, I am doing an internship in the new Team CEPIMMY at the C3M led by Dr Pilar Dominguez. My project aims to investigate different combinatorial epigenetic therapies to treat diffuse large B-cell lymphomas.