The Mediterranean Center for Molecular Medicine (C3M), created in January 2008, is a joint research unit under the governance of Inserm (National Institute of Health and Medical Research) and Université Côte d'Azur (UCA). This research centre is dedicated to translational research into cancer, cardiometabolic diseases and infectious diseases. The association of researchers and clinicians working in C3M creates a synergy based on a common project at the interface between fundamental resarch and clinical research. The C3M is made up of thirteen research teams that maintain fruitful collaborations with doctors and clinicians from a dozen clinical departments of the Nice University hospitals.

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Our research & innovation areas

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Cancer

C3M teams study the molecular and cellular mechanisms involved in cancers such as leukemia, lymphoma, melanoma, prostate, lung and liver cancer. They are also interested in the processes involved in therapeutic resistance and metastasis and in deciphering the tumour microenvironment. Our objectives are to gain a better understanding of these diseases and to identify new therapeutic targets in order to develop new treatments that are more effective and more individual. The research work carried out by our teams places C3M at the forefront of translational research in the field of cancer and has led to the creation of several biotechnology startups.

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Infection and inflammation

The C3M teams are interested in the processes of infection and normal or pathological inflammation. They study the cellular and molecular mechanisms that regulate the virulence of microbes and the immune response during infection or in metabolic diseases, skin diseases and cancers. The new therapeutic targets identified allow the development of drugs and therapies that place C3M at the forefront of translational research on infectious and inflammatory diseases. 

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Metabolic diseases

C3M teams study the mechanisms underlying the development of obesity and cardiometabolic diseases, including insulin resistance, type 2 diabetes, Metabolic Associated Fatty Liver Disease (MAFLD) and cardiovascular diseases. They are interested in the role of adipose tissue dysfunction in insulin resistance, the link between metabolism, immunity and inflammation in the development of cardiometabolic diseases and the progression of hepatic steatosis to Non-Alcoholic SteatoHepatitis (NASH). Our research aims to better understand the mechanisms of the development of these diseases, in order to identify new therapeutic targets and develop innovative therapies. Thanks to close collaboration with the clinical services of Nice University Hospital, the C3M is at the forefront of translational research on metabolic diseases.

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Jobs

Join the C3M teams

Whether you are an engineer, a technician, a post-doctoral fellow, a PhD student or a Master's student, at C3M you will find a stimulating and friendly working environment, with access to cutting-edge technologies on exciting research topics to build and develop the health of tomorrow together.

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Training

Training at C3M

C3M prepares students in Biology and Medicine for research careers in the fields of cancer, cardiometabolic diseases and infectious and inflammatory diseases. More than 15 PhD students defend their thesis at C3M each year. Each year, C3M also welcomes 25 to 30 students from the Biology and Medicine departments on Master's internships, as well as students with a two-year or engineering degree (BTS, IUT and Polytech Nice Sophia). The students benefit from personalized support for technical and theoretical training in research, the writing of their internship report or their thesis, and the oral presentation of their scientific work.