We are delighted to welcome Pr Ian Ganley (head of a team focusing on the Molecular analysis of autophagy and mitophagy in health and diseases, University of Dundee, UK). He will be presenting a seminar entitled:
Kinase Control of Mitophagy
Autophagy is a cell-protective mechanism that prevents the accumulation of damaging cellular “junk” that if left to persist could lead to numerous diseases, including cancer and neurodegeneration. We are predominantly interested in mitophagy - the autophagy mitochondria, which is an essential mitochondrial quality control pathway that has strong links to Parkinson’s disease. In the first part of this talk, I will provide an overview of the physiological instances of mitophagy and discuss our data on the role of the Parkinson’s-related kinase, PINK1, in clearing damaged mitochondria. In the second part of the talk, I will present some unpublished data on how the AMP-activated protein kinase (AMPK) regulates the autophagy-initiating kinase ULK1 during mitophagy to ensure that only damaged (and not functional) mitochondria are turned over.
Slots will be made available on demand to schedule meetings with Ian.